Biochem/physiol Actions

Primary TargetD₁

General description

A benzazepine derivative that acts as a selective Dopamine D₁/D₅ receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Trampus, M. et al. 1993. J. Pharmacol.235, 83.Cooper, S. J. et al. 1990. Psychopharmacol.100, 182.Dubois, A. et al. 1986. Neurosci.19, 125.Kaiser, C. C. et al. 1982. J. Med. Chem.25, 697.

Packaging

5 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)