Biochem/physiol Actions

Primary Target5-HT Uptake Transporter

General description

A very potent uptake inhibitor highly selective for 5-HT transporter (K_i = 0.065 nM and 0.05 nM for human and rat 5-HT transporters, respectively). A popular antidepressant drug of the SSRI type. Used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Brittain, G., et al. 2012. Profiles of drug substances, excipients, and related methodology.38, 407.Bourin, M., et al. 2001. CNS Drug Rev.7, 25.Thomas, R., et al. 1997. Psychopharmacology (Berl).93, 193.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)