PIM-Kinase Inhibitor IX; SGI-1776

Code: 526528-10MG D2-231

General description

A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activiti...


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Your Price
€276.40 10MG
€339.97 inc. VAT

General description

A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 µM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50﹤10 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Chen, L.S., et al. 2011. Blood118, 693.Chang, M., et al. 2010. Mol. Cancer Ther.9, 2478.Mumenthaler, S.M., et al. 2009. Mol. Cancer Ther.8, 2882.Chen, L.S., et al. 2009. Blood 114, 4150.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Reconstitution

Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥99% (HPLC)
coloroff-white
formpowder
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
SMILES stringCN(CC1)CCC1CNC(C=C2)=NN3C2=NC=C3C4=CC(OC(F)(F)F)=CC=C4
solubilitywater: 100 mg/mL, clear, nearly colorless, DMSO: 100 mg/mL, clear, nearly colorless
storage conditiondesiccated (hygroscopic), protect from light, OK to freeze
storage temp.2-8°C
Cas Number1173928-26-1
This product has met the following criteria to qualify for the following awards:



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