Biochem/physiol Actions

Target IC₅₀: 390 nM against poly(ADP-ribose) polymerase (PARS)

Reversible: no

Product does not compete with ATP.

Primary TargetPoly(ADP-ribose) polymerase (PARS)

Cell permeable: yes

General description

A potent, cell-permeable inhibitor of poly(ADP-ribose) polymerase (PARS; IC₅₀ = 390 nM). Blocks nitric oxide-induced neuronal toxicity.

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kamoshima, W., et al. 1997. Neurochem. Int. 30, 305.Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.Zhang, J., et al. 1994. Science 263, 687.Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)