Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetPromotes tubulin depolymerization

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (K_d﹤2 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Park, H., et al. 2011. Chem. Med. Chem.in press.Bunz, F., et al. 1998. Science 282, 1497.Fleischman, L.F., et al. 1993. Oncogene8, 771.Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)