MG WHI-P180; Hydrochloride 1PC x 1MG

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC₅₀: 1 µM for Cdk2

Product does not compete with ATP.

Primary TargetCdk2

General description

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC₅₀ = 1 µM) by blocking the ATP site.

A potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC₅₀ = 1 µM) by blocking the ATP site.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.Chen, C.L., et al. 1999. Pharm. Res. 16, 117.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)