384620-10MG Display Image

MG Honokiol 1PC X 10MG

Code: 384620-10MG D2-231

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAnti-angiogenic, anti-tumor and anxiolytic proper...


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Your Price
€203.94 10MG
€250.85 inc. VAT

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAnti-angiogenic, anti-tumor and anxiolytic properties

General description

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.

The active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bai, X., et al. 2003. J. Biol. Chem.278, 35501.Yang, S.E., et al. 2002. Biochem. Pharmacol.63, 1641.Son, H.J., et al. 2000. Planta Med.66, 469.Maruyama, Y., et al. 1998. J. Nat. Prod.61, 135.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥98% (HPLC)
colorwhite
formsolid
InChI keyFVYXIJYOAGAUQK-UHFFFAOYSA-N
InChI1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 10 mg/mL, ethanol: soluble
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number35354-74-6
This product has met the following criteria: