MG Bax Channel Blocker 1PC x 5MG

Biochem/physiol Actions

Reversible: no

Primary TargetBax-channel forming activity

Product does not compete with ATP.

Target IC₅₀: 520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay

Cell permeable: yes

General description

A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC₅₀ = 520 nM in a liposome channel assay).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Peixoto, P., et al. 2009. Biochem J.423, 381.Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)