General description

A cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC₅₀ = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk′s, and PI 3-Kγ (IC₅₀ >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pelletier, J.P., et al. 2003. Arthritis Rheum.48, 1582.Ciruela, A., et al. 2003. Br. J. Pharmacol.138, 751.Bhattachar, S.N., et al. 2002. Int. J. Pharm.236, 135.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)