Biochem/physiol Actions

Target IC₅₀: 5.6 µM against JAK3

Reversible: yes

Product competes with ATP.

Cell permeable: yes

Primary TargetJAK-3

General description

A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC₅₀ = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.

A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3. Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-jun in DT-40 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ghosh, S., et al. 2001. Acta Crystallogr. C.57, 76.Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.Narla, R.K., et al. 1998. Clin Cancer Res.4, 2463.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)