General description

Inhibits the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP) by interacting with the catalytic domain of FGFR1. Also inhibits aFGF-induced phosphorylation of ERK1 and ERK2 (IC₅₀ = 10-20 µM). In contrast to SU4984, it acts only as a weak inhibitor of tyrosine phosphorylation of the PDGF receptor. Does not inhibit the phosphorylation of insulin receptor and exhibits no inhibitory effect on EGF receptor kinase.

Legal Information

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Mohammadi, M., et al. 1997. Science 276, 955.

Packaging

Packaged under inert gas

500 µg in Plastic ampoule

Physical form

A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572630) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Warning

Toxicity: Irritant (B)