InSolution Akt Inhibitor V; Triciribine

General description

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Karst, A., et al. 2006. Cancer Res.66, 9225.Yang, L., et al. 2004. Cancer Res.64, 4394.

Packaging

Packaged under inert gas

2 mg in Glass bottle

Physical form

A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.

Reconstitution

Following intitial thaw, aliquot and freeze (-70°C).

Warning

Toxicity: Irritant (B)