General description

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Eggert, A., et al. 2001. Cancer Res.61, 1314.Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.Zhu, W.G., et al. 2001. Cancer Res.61, 1327.Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.Haaf, T. 1995. Pharmacol. Ther.65, 19.Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Physical form

A 100 mM (10 mg/438 µl) solution of 5-Aza-2'-Deoxycytidine (Cat. No. 189825) in DMSO.

Warning

Toxicity: Regulatory Review (Z)