Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Target IC₅₀: 1 µM against Gsk-3β

Cell permeable: yes

General description

A thienyl α-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.

A cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Conde, S., et al. 2003. J. Med. Chem.46, 4631.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.

Warning

Toxicity: Standard Handling (A)