Fmoc--2-(7-octenyl)Ala-OH,

Code: F6562-1G D2-231

Application

Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a d...


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€443.00 1G
€544.89 inc. VAT
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Application

Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.

Packaging

1, 5 g in glass bottle

application(s)peptide synthesis
formsolid
functional groupFmoc
InChI keyMADFVGMQNXRFAF-AREMUKBSSA-N
InChI1S/C26H31NO4/c1-3-4-5-6-7-12-17-26(2,24(28)29)27-25(30)31-18-23-21-15-10-8-13-19(21)20-14-9-11-16-22(20)23/h3,8-11,13-16,23H,1,4-7,12,17-18H2,2H3,(H,27,30)(H,28,29)/t26-/m1/s1
Quality Level200
reaction suitabilityreaction type: Fmoc solid-phase peptide synthesis
SMILES stringO=C(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)N[C@@](CCCCCCC=C)(C)C(O)=O
storage temp.−20°C
Cas Number945212-26-0
This product has met the following criteria to qualify for the following awards:



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