General description

ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.^1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.¹ ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).^1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.¹ ERG has also been observed to be positive in a minority of Ewing sarcomas.² This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).⁵ ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.¹

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

ERG Positive Control Slides, Product No. 434S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality