Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC₅₀: 300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively

Product does not compete with ATP.

General description

Inhibitor useful for elucidating roles of protein kinase C. Inhibits diacylglycerol (DAG) kinase in isolated platelet membranes (IC₅₀ = 300 nM) and in intact platelets (IC₅₀ = 120 nM). A more potent analog of DAG kinase inhibitor I.

Inhibits diacylglycerol kinase in isolated platelet membranes (IC₅₀ = 300 nM) and in intact platelets (IC₅₀ = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Jiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.Jones, D.R., et al. 1999. J. Biol. Chem.274, 16846.Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem.264, 3274.

Packaging

5 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)