Biochem/physiol Actions
Cell permeable: no
Reversible: no
Primary TargetDiacylglycerol Kinase
Product does not compete with ATP.
General description
Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC50 = 3.6 µM) and in isolated membranes (IC50 = 6.7 µM). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC50 = 10 µM) but has no effect on the 150 kDa DAG kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin-S2 antagonist.
Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC50 = 2.8 µM) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D2 and histamine H1 antagonist and strong serotonin S2 antagonist.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Goin, M., et al. 1993. FEBS Lett. 316, 68.Ohtsuka, T., et al. 1990. J. Biol. Chem.265, 15418.de Chaffoy de Courcelles, D., et al. 1985. J. Biol. Chem.260, 15762.
Packaging
5 mg in Plastic ampoule
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Warning
Toxicity: Irritant (B)
Quantity
Est. Dispatch/Availability