Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetMobilizes calcium from intracellular stores

General description

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃-independent pathway. Activates phospholipase D (PLD) and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss/3T3 fibroblasts. Inhibits activation of caspases that cleave PARP and lamins during Fas- and ceramide-mediated apoptosis.

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃ independent pathway. Activates phospholipase D and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss 3T3 fibroblasts.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Cuvillier, O., et al. 1998. J. Biol. Chem. 273, 2910.Mattie, M., et al. 1994. J. Biol. Chem.269, 3181.Olivera, A. and Spiegel, S. 1993. Nature365, 557.Desai, N.N., et al. 1992. J. Biol. Chem.267, 23122.Sadahira, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 9686.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Preparation Note

Slight warming and vortexing may be required.

Reconstitution

Following reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20°C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20°C.

Warning

Toxicity: Irritant (B)