CFTR Inhibitor-172

Code: 219670-5MG D2-231

Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Primary TargetCFTR

Target Ki: ~ 300 nM against CFTR (cystic fibrosis t...


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€251.60 EACH
€309.47 inc. VAT

Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Primary TargetCFTR

Target Ki: ~ 300 nM against CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells

Cell permeable: yes

General description

A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50 mM solution in DMSO (Cat. No. 219674).

A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yang, H., et al. 2003. J. Biol. Chem.278, 35079.Al-Awqati, Q., et al. 2002. J. Clin. Invest.110, 1599.Ma, T., et al. 2002. J. Clin. Invest.110, 1651.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥95% (HPLC)
coloryellow
formsolid
InChI keyJIMHYXZZCWVCMI-ZSOIEALJSA-N
InChI1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 5 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number307510-92-5
This product has met the following criteria to qualify for the following awards:



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