Biochem/physiol Actions
Reversible: no
Primary Targetcalpain 1, calpain 2
Product does not compete with ATP.
Cell permeable: yes
General description
A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.
A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.Rami, A., et al. 1997. Neurosci. Res. 27, 93.Yamazaki, T., et al. 1997. Biochemistry36, 8377.Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.Chard, P.S., et al. 1995. Neuroscience 65, 1099.Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
Packaging
25 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Sequence
Z-Val-Phe-CHO
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: