Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetETA (endothelin) receptor antagonist
Target Ki: 40 nM for ETA versus 2.5 µM for ETB
General description
A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 µM for ETB).
A highly potent and selective ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus 2.5 µM for ETB).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Nambi, P., et al. 1996. J. Pharmacol. Exp. Ther.277, 1567.Bax, W.A., and Saxena, P.R. 1994. Trends Pharmacol. Sci. 15, 379.Ihara, M., et al. 1991. Biochem. Biophys. Res. Commun. 178, 132.
Packaging
Yes
Physical form
Supplied as a sodium salt. Sold on the basis of peptide content.
Sequence
Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp, Na)
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria: