Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetETA (endothelin) receptor antagonist

Target K_i: 40 nM for ETA versus 2.5 µM for ETB

General description

A highly potent, selective, and competitive ET_A (endothelin) receptor antagonist (K_i = 40 nM for ET_A versus K_i = 2.5 µM for ET_B).

A highly potent and selective ET_A (endothelin) receptor antagonist (K_i = 40 nM for ET_A versus 2.5 µM for ET_B).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Nambi, P., et al. 1996. J. Pharmacol. Exp. Ther.277, 1567.Bax, W.A., and Saxena, P.R. 1994. Trends Pharmacol. Sci. 15, 379.Ihara, M., et al. 1991. Biochem. Biophys. Res. Commun. 178, 132.

Packaging

Yes

Physical form

Supplied as a sodium salt. Sold on the basis of peptide content.

Sequence

Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp, Na)

Warning

Toxicity: Standard Handling (A)