BIS-IMIDAZOLE PHENOL IDH1 INHIBITOR

Code: SML1430-25MG D2-231

Biochem/physiol Actions

Bis-imidazole phenol blocks D-2-hydroxyglutaric acid synthesis in cells.

bis-Imidazole phenol is a potent and cell permeable inhibitor of isocit...


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Your Price
€628.00 25MG
Discontinued
€772.44 inc. VAT

Biochem/physiol Actions

Bis-imidazole phenol blocks D-2-hydroxyglutaric acid synthesis in cells.

bis-Imidazole phenol is a potent and cell permeable inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant R132H that inhibits D-2-hydroxyglutaric acid (2HG) production in cells. bis-Imidazole phenol binds to an IDH1 R132H allosteric site at the dimer interface containing residue involved in binding of the catalytically essential divalent cation.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyPCIJWPBOCDNTJF-UHFFFAOYSA-N
InChI1S/C22H30N4O/c1-21(2,3)14-22(4,5)19-10-17(12-25-8-6-23-15-25)20(27)18(11-19)13-26-9-7-24-16-26/h6-11,15-16,27H,12-14H2,1-5H3
Quality Level100
SMILES stringOC1=C(CN2C=CN=C2)C=C(C(C)(CC(C)(C)C)C)C=C1CN3C=NC=C3
solubilityDMSO: 30 mg/mL, clear
storage temp.2-8°C
Cas Number1648909-73-2
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