Anti-PCAF

Code: AV32466-100UL D2-231

Application

Rabbit Anti-PCAF antibody can be used for western blot applications at a concentration of 2.5µg/ml.

Biochem/physiol Actions

CBP ...


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Your Price
€470.60 100UL
Discontinued
€578.84 inc. VAT

Application

Rabbit Anti-PCAF antibody can be used for western blot applications at a concentration of 2.5µg/ml.

Biochem/physiol Actions

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

PCAF is a histone acetylase that functions as a nuclear receptor coactivator. Studies have reported that PCAF acetylates p53 sites in vitro.Rabbit Anti-PCAF antibody recognizes rat, bovine, chicken, zebrafish, canine, mouse, and human PCAF.

Immunogen

Synthetic peptide directed towards the N terminal region of human PCAF

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: LFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAK

antibody formIgG fraction of antiserum
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration0.5 mg - 1 mg/mL
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... PCAF(8850)
mol wt93 kDa
NCBI accession no.NP_003875
Quality Level100
shipped inwet ice
species reactivityhuman, dog, guinea pig, rat, mouse, horse, bovine, rabbit
storage temp.−20°C
technique(s)western blot: suitable
UniProt accession no.Q92831
This product has met the following criteria to qualify for the following awards:



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