Anti-LEMD3

Code: ABS460 D2-231

Analysis Note

ControlHuman colon tissue lysate

Application

Anti-LEMD3 Antibody is a highly specific rabbit polyclonal antibody, that targets LEM ...


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Analysis Note

ControlHuman colon tissue lysate

Application

Anti-LEMD3 Antibody is a highly specific rabbit polyclonal antibody, that targets LEM domain-containing protein 3 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected LEMD3 in human colon tissue.

Research CategorySignaling

Research Sub CategoryDevelopmental Signaling

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

LEM domain-containing protein 3 (LEMD3), also known as Inner nuclear membrane protein Man1 (MAN1), is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells. Additionally, LEMD3 is shown to Interact with SMAD1, SMAD2, SMAD3 and SMAD5. Studies also show that LEMD3 binds to both the phosphorylated and the unphosphorylated R-SMADS. LEMD3 is expressed in heart, brain, placenta, lung, liver and skeletal muscle. Defects in LEMD3 are shown to cause disorders, such as osteopoikilosis, Buschke-Ollendorff syndrome (BOS), and melorheostosis (MEL).

Immunogen

KLH-conjugated linear peptide corresponding to human LEMD3.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LEMD3 in 15 µg of human colon tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~120 kDa observed. Uncharacterized bands may appear in some lysate(s).

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... LEMD3(23592)
purified byaffinity chromatography
Quality Level100
shipped inwet ice
species reactivityhuman
technique(s)western blot: suitable, immunohistochemistry: suitable
UniProt accession no.Q9Y2U8
This product has met the following criteria to qualify for the following awards:



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