Biochem/physiol Actions

KIAA1456 might be involved in the regulation of the translation of specific protein(s) via the methyltransferase activity. It negatively regulates tumor growth and the mRNA is downregulated in breast, bladder, colorectal, cervical and testicular carcinomas.

General description

Mouse polyclonal antibody raised against a full-length human KIAA1456 protein. The gene KIAA1456 is mapped to human chromosome 8. It has an SAM (S-adenosyl methionine)-dependent methyltransferase domain.

Immunogen

KIAA1456 (NP_065895, 1 a.a. ~ 367 a.a) full-length human protein.SequenceMVCDNLNLPFRDEGFDAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRRFEKQDVLVPWNRALCSQLFSESSQSGRKRQCGYPERGHPYHPPCSECSCSVCFKEQGGSKRSHSVGYEPAMARTCFANISKEGEEEYGFYSTLGKSFRSWFFSRSLDESTLRKQIERVRPLKNTEVWASSTVTVQPSRHSSLDFDHQEPFSTKEQSLDEEVFVESSSGKHLEWLRAPGTLKHLNGDHQGEMRRNGGGNFLDSTNTGVNCVDAGNIEDDNPSASKILRRISAVDSTDFNPDDTMSVEDPQTDVLDSTAFMRYYHVFREGELCSLLKENVSELRILSSGNDHGNWCIIAEKKGGCD

Physical form

Solution in phosphate buffered saline, pH 7.4