SAB3500209-100UG Display Image

Anti-AGTR1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

Code: SAB3500209-100UG D2-231


Anti-AGTR1 antibody produced in rabbit has been used in in situ proximity ligation assay (PLA) and immunoblotting.

Rabbit polyclonal anti-AGTR1 is ...

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€492.71 100UG


Anti-AGTR1 antibody produced in rabbit has been used in in situ proximity ligation assay (PLA) and immunoblotting.

Rabbit polyclonal anti-AGTR1 is used to tag angiotensin II receptor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of angiotensin II receptor in the regulation of processes that affect vascular functions such as blood pressure and blood flow.

Biochem/physiol Actions

Angiotensin II receptor, type 1 (AGTR1) has a key function in vascular smooth muscle contraction and maintenance of vasopressor effects by controlling aldosterone secretion. The binding of angiotensin II to AGTR1 contributes to the proliferation of vascular smooth muscle cells by the activation of G protein. The binding also results in the activation of Ca2+ dependent kinases as IP3 (inositol triphosphate) and MAPK (mitogen-activated protein kinases) for the synthesis of proteins and expression of proto-oncogenes, respectively. AGTR1 is associated with high risk of hypertension and cardiovascular diseases.


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Features and Benefits

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General description

Angiotensin II receptor, type 1 or AT1 receptor (AGRR1, AT1R) is a receptor for the vasoconstriction peptide angiotensin II involved in the regulation of cardiovascular effects such as blood vasoconstriction (blood pressure), aldosterone and vasopressin secretion, cardiac hypertrophy, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.

Angiotensin II receptor, type 1 (AGTR1) is a G-protein coupled receptor possessing seven transmembrane functional domains. AGTR1 gene spanning around 45.1kb, with five exons, is located on human chromosome 3q21−q25. AGTR1 is highly expressed on endothelial cells, monocytes, podocytes, renal vascular smooth muscle cells and renal arteries.

Rabbit polyclonal anti-AGTR1 reacts with mouse, human, and rat angiotensin II receptor.


AGTR1 antibody was raised against a 16 amino acid peptide from near the center of human AGTR1.


The action of this antibody can be blocked using blocking peptide SBP3500209.

Physical form

Supplied in PBS with 0.02% sodium azide.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
formbuffered aqueous solution
Gene Informationhuman ... AGTR1(185)
NCBI accession no.EAW78909
Quality Level100
shipped indry ice
species reactivityrat, mouse, human
storage temp.−20°C
technique(s)indirect ELISA: suitable, western blot: suitable, immunohistochemistry: suitable, immunofluorescence: suitable
UniProt accession no.P30556
Est. Dispatch/Availability