Anti-DBI antibody recognises DBI protein
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Diazepam binding inhibitor (DBI) is an active peptide and exerts many functions in the brain and peripheral tissues. DBI displaces diazepam from benzodiazepine and thereby regulates signal transduction at type A gamma amino butyric acid (GABAA) receptors. DBI is also involved in the synthesis of steroids and neuroactives. DBI regulates glucose stimulated insulin secretion. The levels of DBI in cerebrospinal fluid is associated with depression associated with or without anxiety.
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Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.
Diazepam binding inhibitor (DBI) is a peptide also known as acyl-coenzyme A binding protein. DBI is majorly expressed in the central nervous system. DBI is also expressed in the peripheral tissues, where there is high affinity for benzodiazepine recognition sites. The gene encoding for DBI is localised on human chromosome 2q14.2.
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
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Corresponding Antigen APREST87583.
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.