Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetA2PLA2

Cell permeable: yes

General description

Inhibits epinephrine-stimulated thromboxane production (86% at 3.5 µM) via inhibition of phospholipase A₂ (PLA₂) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.

A cell-permeable inhibitor of phospholipase A₂ that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Liu, L., et al. 1999. J. Cell. Biochem.72, 103.Simonsson, E., et al. 1998. Diabetes47, 1436.Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215.Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.

Packaging

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)