4-Cyano-3-methylisoquinoline

Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

Target IC₅₀: 30 nM against protein kinase A

Cell permeable: yes

Primary TargetPKA

General description

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.

A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)