Application
This compound undergoes cycloreversion to form the fluoro(hetero)aryl ketene, which undergoes efficient coupling with nucleophiles and allows rapid incorporation of highly fluorinated α-fluoro(hetero)aryl acetic acid derivatives.
General description
3-Methyl-3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-1,5-dioxaspiro[5.5]undecane-2,4-dione is a substituted Meldrum’;s acid derivative. It can be prepared by reacting octafluorotoluene with 3-methyl-1,5-dioxaspiro[5.5]undecane-2,4- dione.
Other Notes
Selective Perfluoro- and Polyfluoroarylation of Meldrum’;s Acid
Packaging
250 mg in glass bottle
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