3,3,5,5-Tetraiodothyroacetic acid,

Code: T3787-25MG D2-231

Application

3,3′,5,5′-Tetraiodothyroacetic acid has been used: as a positive control to study the effects of ioxynil (IOX) diethylstilbestrol (DES) exposure on zebrafish embr...


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Your Price
€121.20 25MG
€149.08 inc. VAT

Application

3,3′,5,5′-Tetraiodothyroacetic acid has been used: as a positive control to study the effects of ioxynil (IOX) diethylstilbestrol (DES) exposure on zebrafish embryosto study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male ratsto determine its influence on the actions of thyroid-stimulating hormonethyroid-stimulating immunoglobulins in orbital fibroblast

Biochem/physiol Actions

Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1.

3,3′,5,5′-Tetraiodothyroacetic acid (Tetrac) is a deaminated analog of L-thyroxine (T4). It prevents the pro-angiogenesis actions of T4 and 3,5,3′-triiodo-L-thyronine. It is a thyrointegrin receptor antagonist. Tetrac prevents the binding of thyroid hormones.

Linkage

Thyroid hormone analog

Preparation Note

3,3′,5,5′-Tetraiodothyroacetic acid is soluble in acetone at 19.60 - 20.40 mg/ml and yields a clear, faint yellow to yellow solution.

InChI keyPPJYSSNKSXAVDB-UHFFFAOYSA-N
InChI1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20)
Quality Level200
SMILES stringOC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1
solubilityacetone: soluble 19.60-20.40 mg/mL, clear, colorless (or faintly yellow to yellow)
storage temp.−20°C
Cas Number67-30-1
Hazard Class6.1
Un Number2811
Pack GroupI
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