17-Dimethylaminoethylamino-17-demethoxygeldanamycin,

Code: D5193-1MG D2-231

Application

17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).


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€389.00 1MG
€478.47 inc. VAT
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OVERVIEW

Application

17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).

Biochem/physiol Actions

17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.

General description

Chemical structure: benzenoid

SPECIFICATIONS
antibiotic activity spectrumneoplastics
biological sourcesynthetic
colordark red-purple to black
formpowder
mode of actionprotein synthesis | interferes
Quality Level100
solubilityethanol: ~10 mg/mL (lit.), DMSO: >25 mg/mL (lit.)
storage temp.−20°C
DOCUMENTS
RANGE
ATTRIBUTES
Cas Number467214-20-6
This product has met the following criteria to qualify for the following awards:



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