Application

Q-VD-OPh hydrate has been used:as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)to induce canonical caspase-dependent apoptosis in UC cells to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells

Biochem/physiol Actions

Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

1, 5 mg in glass bottle