GSK0660, >=98% (HPLC)

Code: G5797-5MG D2-231

Application

GSK0660 has been used to study the effects of bezafibrate (BZA) on hypertrophy.

Biochem/physiol Actions

GSK0660 is a potent PPARβ...


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Your Price
€203.42 5MG
Discontinued
€250.21 inc. VAT

Application

GSK0660 has been used to study the effects of bezafibrate (BZA) on hypertrophy.

Biochem/physiol Actions

GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (160 nM). GSK0660 is nearly inactive on PPARα and PPARγ with IC50s greater than 10 µM.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

GSK0660 has antiangiogenic property in oxygen-induced retinopathy. It also regulates tumor necrosis factor-α (TNFα)-induced inflammation in human retinal microvascular endothelial cells (HRMECs).

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyNDFKBGWLUHKMFY-UHFFFAOYSA-N
InChI1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3
originatorGlaxoSmithKline
SMILES stringCOC(=O)c1sccc1S(=O)(=O)Nc2ccc(Nc3ccccc3)cc2OC
solubilityDMSO: 10 mg/mL, clear
storage temp.2-8°C
Cas Number1014691-61-2
This product has met the following criteria to qualify for the following awards:



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