Biochem/physiol Actions

STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates the transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.Mutations in STUB1 (STIP1 homology and U-box containing protein 1) result in autosomal recessive cerebellar ataxia (ARCA). The carboxyl terminus of the Hsc70?interacting protein (CHIP) has the ability to stimulate ubiquitination and degradation of various oncogenic proteins. It also plays a vital role in blocking tumor progression and invasion.

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General description

STUB1 (STIP1 homology and U-box containing protein 1) codes for CHIP (C-terminus of HSC70-interacting protein). It is located on human chromosome 16p13.3.

Immunogen

Synthetic peptide directed towards the C terminal region of human STUB1

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: VDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHF