Application

Anti-TCF21 antibody produced in rabbit has been used in:immunofluorescenceflow cytometrychromatin immunoprecipitation

Biochem/physiol Actions

Transcription factor TCF21 (TCF21) regulates mesenchymal-to-epithelial differentiation and smooth muscle cells (SMCs) phenotypic modulation. The deletion of TCF21 gene leads to SMC upregulation. Hypermethylation of TCF21 is implicated in non-small cell lung cancer (NSCLC). TCF21 is a tumor suppressor and is involved in the invasion and metastasis. Elevated expression of TCF21 leads to hepatocellular cancer suppression. It also elicits anti-angiogenic activity in cholangiocarcinoma. TCF21 locus is also associated with coronary heart disease(CAD).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

Transcription factor TCF21 (TCF21) or capsulin, expressed in proepicardial cells is mapped to human chromosome 6q23.2.

Immunogen

transcription factor 21 recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST85233.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.