Biochem/physiol Actions

Eosinophil cells expressing CD48 (cluster of differentiation 48) receptors play an important role in allergic reactions induced by toxins such as those produced by Staphylococcus aureus. CD48 acts as a costimulator to activate T-lymphocytes as part of immune response. It also serves as an adhesion molecule.

General description

CD48 antigen is also known as Signaling lymphocytic activation molecule 2, SLAM family member 2 (SLAMF2), Leukocyte antigen MEM-102, BCM1 surface antigen, B-lymphocyte activation marker BLAST-1. CD48 is a 65 kDa GPI-linked protein which belongs to the CD2 subfamily of immunoglobulin superfamily molecules. CD48 antigen contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domain. CD48 interacts with CD244 in an heterophilic manner. CD48 is ligand for CD2. CD48 might facilitate interaction between activated lymphocytes. CD48 is probably involved in regulating T-cell activation.CD48 (cluster of differentiation 48) is soluble receptor, expressed on haematopoietic cell surface. It is a glycosylphosphatidylinositol anchored protein and belongs to the CD2 family. The CD48 gene is mapped to human chromosome 1q23.3.

Physical form

Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.