Application

γ-Globulins from bovine blood has been used along with polyethylene glycol (PEG) to investigate the kinetics of liquid-liquid phase separation (LLPS) in its temporary and arrested state. It has also been used as a parent solution to prevent bacterial growth and study the antibody system with LLPS and highly elevated protein concentrations in arrested transition.

Bovine γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.

Biochem/physiol Actions

Immunoglobulins are implicated in theactivation of the complement system and the opsonization of microbesforphagocytosis. It is also involved in the neutralization of toxins and viruses and blockstheattachment of microbes to mucosal surfaces. Theyprotectour bodiesagainst fungi, viruses, and bacteria. Immunodeficiencyis associated withrecurrent infectiousdiseases.

General description

Plasma protein fraction rich in antibodies

γ-Globulinsare immunoglobulinsthat contain IgM, IgA, andIgY.They areglycoproteins produced by plasmacells.The immunoglobulins areheterodimericmolecules comprisingtwo light chains and two heavy chains linked together by disulfidebonds.

Preparation Note

Prepared from Cohn Fraction II, III