Biochem/physiol Actions

M871 is a type 2-selective galanin receptor antagonist (GalR2/GalR1 K_i = 13.1/410 nM by competitive binding against 0.1 nM porcine galanin using membranes from CHO expressing respective human receptors; GalR2/GalR1 K_i = 2.5/1.1 nM in case of rat galanin) that potently blocks 10 nM rat galanin-induced inositol phosphate production in human GalR2-expressing CHO cells (by 100% with 0.1, 1 or 10 nM M871). M871 is widely employed in cultures (0.1 nM-2.5 µM) and in mice and rats in vivo via ip., brain region- or other site-specific injections.