BETRIXABAN

Code: SML2845-25MG D2-231

Biochem/physiol Actions

Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki ...


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Biochem/physiol Actions

Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC50 = 6.3 µM) and little potency against thrombin, trypsin, t-PA, aPC or plasmin inhibition (IC50 >10 µM). Betrixaban exhibits good pharmacokinetic properties and anticoagulant efficacy against various thromboembolism (VTE) events in vivo.

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
SMILES stringClC1=CN=C(C=C1)NC(C2=C(NC(C3=CC=C(C(N(C)C)=N)C=C3)=O)C=CC(OC)=C2)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number330942-05-7
This product has met the following criteria to qualify for the following awards:



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