THAL-SNS-032

Code: SML2686-1MG D2-231

Biochem/physiol Actions

THAL-SNS-032 is a selective inhibitor and degrader of cyclin-dependent kinase 9 (CDK9). It links the CDK inhibitor SNS-032 to a thalidomide derivative...


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Biochem/physiol Actions

THAL-SNS-032 is a selective inhibitor and degrader of cyclin-dependent kinase 9 (CDK9). It links the CDK inhibitor SNS-032 to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon. THAL-SNS-032 was found to selectively induce degradation of CDK9 over other CDKs. It inhibited proliferation across a panel of 11 different leukemia cancer cell lines potently than SNS-032.

assay≥98% (HPLC)
colorwhite to beige
formpowder
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
Cas Number2139287-33-3
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