TT-10

Code: SML2658-5MG D2-231

Biochem/physiol Actions

TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase ...


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Biochem/physiol Actions

TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 µM TT-10 over untreated control = 5.2/rat CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression.

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
SMILES stringNC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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