REPARIXIN

Code: SML2655-5MG D2-231

Biochem/physiol Actions

Reparixin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2 with IC50 values of 1 nM for C...


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Biochem/physiol Actions

Reparixin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2 with IC50 values of 1 nM for CXCR1 and 100 nM for CXCR2. It is believed to prevent receptor signaling by locking CXCR1/R2 in an inactive conformation. Reparixin has been studied to prevent ischaemia-reperfusion injury and inflammation and is clinical trials for triple negative breast cancer and to prevent injury occurring after pancreatic islet transplantation.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyKQDRVXQXKZXMHP-UHFFFAOYSA-N
InChI1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)
optical activity[α]/D -80 to -90°, c = 1.0 in ethanol
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
Cas Number266359-83-5
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