CA3

Code: SML2647-25MG D2-231

Biochem/physiol Actions

CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activi...


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Biochem/physiol Actions

CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity.

assay≥97% (HPLC)
colorwhite to beige
formpowder
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
Cas Number300802-28-2
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