JH-I-25

Code: SML2609-5MG D2-231

Biochem/physiol Actions

JH-I-25 is a potent and selective type I inhibitor of IRAK1 and IRAK4 (interleukin-1 receptor–associated kinase 1 and 4). JH-I-25 binds preferen...


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Biochem/physiol Actions

JH-I-25 is a potent and selective type I inhibitor of IRAK1 and IRAK4 (interleukin-1 receptor–associated kinase 1 and 4). JH-I-25 binds preferentially to the unphosphorylated the ATP-site of the kinase in its active, DFG-in, state.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringO=C(NC1=C(C=C(C=C1)N2CCOCC2)OC)C3=NC(C4=NNC=C4)=CC=C3
solubilityDMSO: 2 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number1042673-20-0
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