CSRM617 HYDROCHLORIDE

Code: SML2608-25MG D2-231

Biochem/physiol Actions

CSRM617 is an ONECUT2 (OC2) inhibitor that directly targets OC2 HOX domain (KD = 7.43 µM) and disrupts OC2 target genes promoter binding. CSRM617...


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Biochem/physiol Actions

CSRM617 is an ONECUT2 (OC2) inhibitor that directly targets OC2 HOX domain (KD = 7.43 µM) and disrupts OC2 target genes promoter binding. CSRM617 blocks OC2-dependent prostate cancer growth in cultures (IC50 = 4-50 µM; 48 h) via apoptosis induction (fold of untreated annexin V population = 2.3/10 µM, 3.5/20 µM; 22Rv1) and exhibits in vivo efficacy against metastases as well as the growth of established 22Rv1 tumor in mice in vivo (50 mg/kg/day ip.).

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringOC1=C(C=CC(O)=C1O)C=NNC(C(CO)N)=O.Cl
solubilityH2O: 2 mg/mL, clear
storage conditiondesiccated
storage temp.−20°C
Cas Number1353749-74-2
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