51164

Code: SML2605-5MG D2-231

Biochem/physiol Actions

51164 is a neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates neuronal store-operated calcium entry...


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Biochem/physiol Actions

51164 is a neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates neuronal store-operated calcium entry (nSOCE) in the hippocampal neurons spines. 51164 fully rescues mushroom spines in Aß42-treated neurons. It restores long-term potentiation (LTP) deficit in 6 months old hippocampal slices from 5xFAD mouse model.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringO=C(NC1=CC=CC=C1Cl)CN(CC2)CCN2C3=CC=CC=C3
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number361473-63-4
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