RAPHIN1

Code: SML2562-5MG D2-231

Biochem/physiol Actions

Raphin1 is an orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B). It d...


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Biochem/physiol Actions

Raphin1 is an orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B). It does not inhibit PP1c. Raphin1 transiently decreases protein synthesis in cells. It is efficacious in mouse model of Huntington’;s disease.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyWLTSTDGGFCQWTK-YIXHJXPBSA-N
InChI1S/C8H8Cl2N4/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
shipped inwet ice
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
Cas Number94023-67-3
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