ML162

Code: SML2561-25MG D2-231

Biochem/physiol Actions

ML162 is a small molecule that induces ferroptosis via covalent inhibition of cellular phospholipid glutathione peroxidase (GPX-4; GPX4; GSHPx-4; PHGP...


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€362.40 25MG
€445.75 inc. VAT
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Biochem/physiol Actions

ML162 is a small molecule that induces ferroptosis via covalent inhibition of cellular phospholipid glutathione peroxidase (GPX-4; GPX4; GSHPx-4; PHGPx; snGPx; snPHGPx). Synthetic lethality studies in cancer cultures identify contributing factors such as HRas(G12V) expression and fumarate hydratase (FH) deletion to ML162 sensitivity (IC50 = 25 nM & 35 nM, respectively, in BJeLR-HRas(G12V) & UOK262-FH-/- cultures).

assay≥98% (HPLC)
colorwhite to very dark brown
formpowder
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number1035072-16-2
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